Table 3:
OR for asthma and allergic diseases at ages 5 and 13 (MMR-vaccinated/non-MMR-vaccinated)
| Adjustment for variables associated to MMR 1 | Adjustment for additional potential confounders 12 | Adjustment for asthma/allergy at age 5 13 | Sensitivity analyses 14 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | N | OR (95% CI) |
p | N | OR (95% CI) |
p | N | OR (95% CI) |
p | N | OR (95% CI) |
p |
| 5 years | ||||||||||||
| Asthma (questionnaire) | 483 | 0.33 (0.12; 0.90) |
0.03 | 425 | 0.32 (0.10; 1.05) |
0.06 | 479 | 0.55 (0.16; 1.82) |
0.33 | |||
| Hypersensitivity/allergy (questionnaire) | 481 | 0.32 (0.11; 0.88) |
0.03 | 421 | 0.36 (0.11; 1.21) |
0.10 * | 477 | 0.36 (0.11; 1.19) |
0.09 | |||
| 13 years | ||||||||||||
| Asthma ever (questionnaire) | 489 | 0.22 (0.08; 0.56) |
0.002 | 431 | 0.16 (0.05; 0.53) |
0.003 | 483 | 0.24 (0.07; 0.82) |
0.02 | 485 | 0.31 (0.10; 0.93) |
0.04 |
| Allergic rhinoconjunctivitis symptoms in the past 12 months (questionnaire) | 489 | 0.64 (0.19; 2.07) |
0.45 | 431 | 0.63 (0.14; 2.71) |
0.53 | 481 | 0.79 (0.22; 2.76) |
0.71 | 485 | 0.65 (0.17; 2.47) |
0.52 |
| Eczema ever (questionnaire) | 489 | 0.73 (0.26; 2.10) |
0.57 | 431 | 0.46 (0.14; 1.52) |
0.21 | 481 | 0.65 (0.24; 1.76) |
0.39 | 485 | 0.65 (0.20; 2.08) |
0.47 |
| Reaction to any allergen in skin prick test | 489 | 0.59 (0.23; 1.53) |
0.28 | 431 | 0.47 (0.16; 1.40) |
0.18 | 485 | 0.73 (0.24; 2.23) |
0.59 | 485 | 0.44 (0.15; 1.28) |
0.13 |
Adjusted for birth weight and family history of chronic bronchitis/asthma. The analyses at age 13 years are additionally adjusted for whether the child had received the second MMR vaccine before the 13-year examination.
Additional adjustment for sex, premature birth, maternal smoking during pregnancy, log(cord blood IgE), breastfeeding, number of older siblings, number of younger siblings, parental smoking in the home, day care, family history of eczema in children/allergic eczema/hay fever, family history of allergy, and age at the examination.
The asthma ever analysis is adjusted for asthma (questionnaire) at age 5, and the allergic rhinoconjunctivitis symptoms, eczema ever, and reaction to SPT analyses are adjusted for hypersensitivity/allergy (questionnaire) at age 5.
Excluding children without any vaccine information.
The hypersensitivity/allergy analysis could not be adjusted for premature birth as none of the prematurely born children had allergy at age 5.