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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Neurobiol Dis. 2018 Sep 6;120:98–106. doi: 10.1016/j.nbd.2018.09.005

Figure 4. Identification of cell-type specific TRNs in IM injected M83+/− and aged M83+/+ end-stage mice.

Figure 4.

Distribution of cell type specific TFs that are commonly enriched (upregulated and downregulated) in αSyn fibril injected M83+/− mice and aged M83+/+ endstage mice (A). Cell type specificity of TFs has been imputed from http://web.stanford.edu/group/barres_lab/brain_rnaseq.html. TFs were either exclusively expressed from one cell type (‘primary’ cell type enrichment) or were present in multiple cell types, with highest (designated as ‘Primary’) and lower expression levels (designated as ‘Secondary’). Only the primary cell type enrichment is mapped here; for immune genes that are expressed equally from microglia, astrocytes and oligodendrocyte progenitor cells, these have been classified as Mg+. We further identified a neuronal-specific TRN and an endothelial cell TRN that are differentially enriched in endstage αSyn fibril (IM) injected M83+/− mice and aged M83+/+ mice respectively (B-C). Thickness of the arrows connecting the TFs in the network denotes rank (1 being the thickest) (B-C). Mixed=all cells; Neu=neuron; Ast=Astrocyte; Mg=Microglia; End=endothelia; OPC=oligodendrocyte progenitor cells.