REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and Virus Strains
RV-1B	ATCC	VR-1645
Biological Samples
Primary human bronchial epithelial cells	LONZA	Cat# CC-2540S
Primary human nasal epithelial cells	Promocell, Germany	Cat# C-12620
Chemicals, Peptides, and Recombinant Proteins
SLR14 RIG-I ligand	provided by Anna Pyle, Yale University	N/A
SLR14–488 RIG-I ligand	provided by Anna Pyle, Yale University	N/A
Cigarette Smoke Extract	provided by Charles Dela Cruz, Yale University	N/A
Critical Commercial Assays
iScript cDNA synthesis Kit	Bio-Rad	Cat# 1708891
iTaq Universal SYBR green	Bio-Rad	Cat# 1725120
RNeasy Mini Kit	QIAGEN	Cat# 74106
Interferon lambda 1 ELISA kit	eBiosciences	Cat# 88–7296-22
Deposited Data
RNASeq data, resting and SLR14 stimulated nasal and bronchial-derived epithelial cells	This paper	GEO: GSE117884
Experimental Models: Cell Lines
Human: H1-HeLa cells	Provided by W.M. Lee	Lee et al., 2015
Oligonucleotides
siRNA negative control (RISC-free)	Dharmacon	Cat# D-001220–01
siRNA targeting NRF2	Dharmacon	Cat# D-003755–01
siRNA targeting MAVS	Dharmacon	Cat# D-024237–02
Primers used for RT-qPCR, see Table S2	This paper	N/A
Software and Algorithms
GraphPad Prism 7.0	GraphPad Software	https://www.graphpad.com
Ingenuity Pathway Analysis software	QIAGEN	https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis
btrim	Kong, 2011	N/A
tophat2	Kim et al., 2013	N/A
DEseq2	Love et al., 2014	N/A