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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 31;61(17):8029–8047. doi: 10.1021/acs.jmedchem.8b01133

Scheme 1. Synthesis of compounds 11a and 11ba.

Scheme 1.

aReagents: (a) pyridine, rt, 18–76% yield; (b) RBr, K2CO3, DMF, rt, 80% yield; (c) NaOH, MeOH, reflux. 67–80% yield; rt: room temperature