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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 31;61(17):8029–8047. doi: 10.1021/acs.jmedchem.8b01133

Scheme 2. Synthesis of 1,4-isoquinolines 15 and 17a.

Scheme 2.

aReagents: (a) PBr5, 140 °C, 89% yield; (b) CuI, N,N’-dimethylethylenediamine, K2CO3, MeCN, 70 °C, 60% yield; (c) RBr, K2CO3, DMF, rt, 77% yield; (d) NaOH, MeOH, reflux, 36% yield. rt: room temperature