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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 31;61(17):8029–8047. doi: 10.1021/acs.jmedchem.8b01133

Scheme 6. Synthesis of compounds 38, 40, and 42a.

Scheme 6.

aReagents: (a) pyridine, rt 55–58% yield; (b) RBr, K2CO3, DMF, rt, 70–80% yield; (c) NaOH, MeOH, reflux, 70–74% yield; (d) F3CCO2H, CH2Cl2, rt, 55% yield. rt: room temperature