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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 31;61(17):8029–8047. doi: 10.1021/acs.jmedchem.8b01133

Scheme 7. Synthesis of biphenyl 46.

Scheme 7.

aReagents: (a) phenylboronic acid, Pd(OAc)2, K3PO4, H2O, reflux, quant. yield; (b) SnCl2, MeOH, reflux, 99% yield; (c) p-methoxybenzenesulfonyl chloride, pyridine, THF, reflux; (d) ethyl bromoacetate, K2CO3, DMF; (e) NaOH, MeOH, reflux, 51% yield over 3 steps. rt: room temperature