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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 31;61(17):8029–8047. doi: 10.1021/acs.jmedchem.8b01133

Table 2:

Aqueous solubility, shown in μM units ± standard deviation.

Compound Aqueous Solubility (μM)
5 5.4 ± 0.9
6a 440 ± 3
6b 22 ± 9
9b 1.2 ± 0.2
11b 1.2 ± 0.2
11a 190 ± 0.8
15 3.8 ± 0.1
17 380 ± 3
21 6.1 ± 0.1
23 390 ± 4
27 0.86 ± 0.3
29 N.D.b
32 370 ± 7
34 380 ± 7
38 1.3 ± 0.3
40 490 ± 90
42 420 ± 12
46 270 ± 3