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. Author manuscript; available in PMC: 2019 Jan 31.
Published in final edited form as: J Am Chem Soc. 2018 Jan 17;140(4):1184–1194. doi: 10.1021/jacs.7b09446

Table 2.

Pharmacokinetic Properties of 6 and 6-c Observed in Male Sprague—Dawley Rats after Either Intravenous or Oral Administration As Originally Reported in Ref 16a

dose (mg kg1) AUC (nMh)
compd IV PO IV PO F (%) CL (mL min−1 kg−1) t1/2 (h) tmax (h) MRT (h) Cmax(nM)
6-c 0.5 5.0 1261 283 22.5 39.2 10.5 0.5 0.8 692
6 1.0 5.0 2092 613 29.3 23.7 11.6 1.5 2.7 746
a

Abbreviations: AUC = area under the curve (IV, intravenous, or PO, oral) normalized to 1 mg kg−1 dose; F = bioavailability; CL = clearance; MRT = mean residence time.