Table 1.

PICOS criteria outlining study eligibility.

Criteria	Inclusion
Population	Newborns and young infants hospitalized with sepsis or other serious infection in a resource poor/developing country (majority of patients must be < 1 year of age, or a multivariate analysis adjusting for age must be conducted) •Studies conducted in developed countries will be excluded •Studies involving non-admitted patients (ex. Ambulatory or community) or surgical patients will be excluded
Interventions	Usual care, or care during an intervention of any kind*
Comparisons	N/A
Outcomes	Studies must evaluate and report risk factors, along with a risk estimate (OR, RR, etc) or valid statistical analysis for at least one of the following outcomes:
	•In-hospital mortality prior to discharge
	•Post-discharge mortality occurring either in community or upon readmission
Study designs	Studies must be one of the following:
	•Single arm or multi-arm trials
	•Prospective cohort study
	•Retrospective cohort studies
	•One case-control study
Language	English language only

^*Please note that in all studies included except one, the intervention was usual care. If any additional interventions were employed and the results showed statistical significance, the relative risks for the control arm as well as the intervention arm will be described separately in the results section.