Table 2.
Study characteristics.
| Author and year | Study countries | Study perioda | Study type | Study population | Mortality type (IP/PD)b | Total No. of patients | No. of patients who died | No. of patients < 1 month | No. of patients < 1 year |
|---|---|---|---|---|---|---|---|---|---|
| NEONATAL STUDIES (<1 MONTH) | |||||||||
| Basu et al. (18) | India | 1997–2003 | Retrospective | Neonatal tetanus | IP + PD | 101 | 67 | 101 | 101 |
| Ballot et al. (17) | South Africa | 2007–2011 | Retrospective | Neonatal fungal sepsis | IP | 63 | 27 | 63 | 63 |
| Chiabi et al. (20) | Cameroon | 2008–2009 | Prospective | Neonatal sepsis | IP | 218 | 46 | 218 | 218 |
| Daoud et al. (22) | Jordan | 1992–1994 | Prospective | Neonatal meningitis | IP | 53 | 17 | 53 | 53 |
| Davies-Adetugbo et al. (23) | Nigeria | 1991–1995 | Retrospective | Neonatal tetanus | IP | 174 | 96 | 174 | 174 |
| Dikici et al. (25) | Turkey | 1991–2006 | Retrospective | Neonatal tetanus | IP | 67 | 27 | 67 | 67 |
| Ertem et al. (28) | Turkey | 1994–2001 | Retrospective | Neonatal tetanus | IP | 56 | 38 | 56 | 56 |
| Ghiorghis et al. (29) | Ethiopia | 1992–1993 | Retrospective | Neonatal sepsis | IP | 542 | 195 | 542 | 542 |
| Gurkan et al. (31) | Turkey | 1991–1997 | Retrospective | Neonatal tetanus | IP | 55 | 22 | 55 | 55 |
| Gurses et al. (32) | Turkey | 1978–1988 | Retrospective | Neonatal tetanus | IP | 133 | 54 | 133 | 133 |
| Ibinda et al. (33) | Kenya | 1999–2013 | Retrospective | Neonatal tetanus | IP | 191 | 118 | 191 | 191 |
| Mathur et al. (37) | India | NA | Prospective | Neonatal respiratory distress | IP | 150 | 48 | 150 | 150 |
| Mugalu et al. (40) | Uganda | 2002 | Prospective | Neonatal septicemia | IP | 110 | 20 | 110 | 110 |
| Okomo et al. (44) | Gambia | 2009–2013 | Retrospective | All neonatal deaths | IP | 5,285 | 1,734 | 5,285 | 5,285 |
| Okoromah et al. (45) | Nigeria | NA | Retrospective | Neonatal tetanus | IP | 39 | 4 | 39 | 39 |
| Ozkan et al. (46) | Turkey | 2003–2010 | Retrospective | Neonatal sepsis (preterm) | IP | 151 | 22 | 151 | NA |
| Sarna et al. (52) | India | 1988 | Retrospective | All neonatal deaths | IP | 7,309 | 328 | 328 | 328 |
| Saleem et al. (50) | Pakistan | 2006–2011 | Retrospective | Neonatal sepsis | IP | 104 | 17 | 104 | 104 |
| Sheikh et al. (55) | Pakistan | 2012 | Prospective | Neonatal sepsis | IP | 125 | 20 | 125 | 125 |
| Simiyu et al. (56) | Kenya | 2000 | Retrospective | All neonatal deaths | IP | 308 | 97 | 308 | 308 |
| Yaramis et al. (60) | Turkey | 1990–1999 | NA | Neonatal tetanus | IP | 73 | 38 | 73 | 73 |
| INFANT STUDIES (<12 MONTHS) | |||||||||
| Bhatnagar et al. (19) | India | 2005–2008 | RCT | Serious bacterial infection | IP | 848 | 7 | 182 | 848 |
| Coakley et al. (21) | Papua New Guinea | 1989 | Prospective | Measles | IP | 282 | 48 | NA | NA |
| Demers et al. (24) | Central African Republic | 1996–1997 | Prospective | Acute respiratory infections | IP | 395 | 49 | 14 | 222 |
| Djelantik et al. (26) | Indonesia | 1999–2001 | Retrospective | Pneumonia | IP | 4,351 | 505 | NA | NA |
| Duke et al. (27) | Papua New Guinea | 1998–1999 | Prospective | Pneumonia | IP | 703 | 46 | NA | NA |
| Goel et al. (30) | South Africa | 1989–1995 | Retrospective | Staphylococcal pneumonia | IP | 100 | 7 | NA | 78 |
| Islam et al. (62) | Bangladesh | 1991–1992 | Prospective | Diarrhea | PD | 427 | 30 | NA | 329 |
| Khan et al. (34) | Pakistan | 2007–2008 | Retrospective | Sepsis | IP | 133 | 32 | NA | NA |
| Kuti et al. (35) | Nigeria | 2011–2013 | Retrospective | Bacterial meningitis | IP | 81 | 22 | NA | NA |
| Lehmann et al. (36) | Papua New Guinea | 1989–1992 | Prospective | Bacterial meningitis | IP | 696 | 96 | NA | 535 |
| Moisi et al. (39) | Kenya | 2004–2008 | Prospective | General mortality | PD | 14,971 | 535 | NA | NA |
| Mulholland et al. (41) | Gambia | 1990–1991 | Prospective | Serious infections | IP | 697 | 64 | NA | 697 |
| Nantanda et al. (42) | Uganda | 2005–2006 | Prospective | Pneumonia | IP | 157 | 24 | 87 | NA |
| Nathoo et al. (43) | Zimbabwe | 1989–1990 | Prospective | Lower respiratory infection | IP | 704 | 104 | 0 | 502 |
| Ramakishna et al. (47) | Malawi | 2005–2006 | Prospective | Pneumonia | IP | 233 | 25 | 0 | 117 |
| Rodriguez et al. (48) | Columbia | 2009–2011 | Retrospective | Respiratory syncytial virus infection | IP | 2,147 | 25 | NA | 1,549 |
| Sachdev et al. (49) | India | 1988 | Prospective | Diarrhea | IP | 382 | 37 | NA | NA |
| Sehgal et al. (53) | India | 1993–1994 | Prospective | Lower respiratory infection | IP | 201 | 21 | NA | 105 |
| Santhanakrishnan et al. (51) | India | NA | NA | Diarrhea, acute | IP | 575 | 64 | NA | 441 |
| Shann et al. (54) | Papua New Guinea | NA | Prospective | Pneumonia | IP | 47 | 7 | NA | NA |
| Smyth et al. (57) | Zambia | 1994–1995 | Prospective | Pneumonia | IP | 167 | 23 | NA | 104 |
| Tupasi et al. (59) | Philippines | 1981–1983 | Prospective | ALRI | IP | 726 | 34 | NA | 361 |
| Teka et al. (58) | Bangladesh | 1990–1994 | Case-control | Diarrhea | IP | 928 | 46 | NA | NA |
| Zhang et al. (61) | China | 2007–2010 | Prospective | Pneumonia | IP | 707 | 41 | NA | 535 |
All studies cohort unless otherwise specified.
IP, inpatient; PD, post-discharge.