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. 2018 Oct 9;9:1417. doi: 10.3389/fphys.2018.01417

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Copyright © 2018 Ergir, Bachmann, Redl, Forte and Ertl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bridging the in vivo/in vitro gap in mechanobiology. (A) A combination of mechanobiological cues in the microenvironment can regulate cell signaling and phenotype as well as physiological and pathological tissue response. (B) A simplified demonstration of a mechanobiology-on-a-chip, and potential on-chip stimulation strategies for microfluidic 2D/3D cell cultures: (i) Shear stress, (ii) Interstitial flow, (iii) Stretching, (iv) Magnetic stimulation, (v) Micropatterning, (vi) Compression, (vii) Acoustic stimulation, (viii) Magnetic twisting, (ix) Optical tweezers, and (x) Rotation (dielectrophoresis).