Table 1.
Summary on recent reports on mechanobiological approaches for cell manipulation in microfluidic devices.
| Biomechanical stimulus | Organ culture | Cell type | Environment | Reference |
|---|---|---|---|---|
| Interstitial flow | Vasculature | Primary | 3D | Hsu et al., 2013; Jeon et al., 2014; Kim S. et al., 2016 |
| Interstitial flow | Brain | Primary | 3D | Park et al., 2015; Wang et al., 2018 |
| Interstitial flow | Liver | Primary | 3D | Lee et al., 2013 |
| Substrate stiffness | - | Cell line | 2D | García et al., 2015 |
| Electromechanical | - | Primary | 2D | Pavesi et al., 2015 |
| Shear stress | Vasculature | Primary | 2D | Charwat et al., 2018 |
| Shear stress | - | Cell line | 2D | Soffe et al., 2017 |
| Shear stress | Blood brain barrier | Cell line | 2D | Griep et al., 2013 |
| Shear stress | Aortic valve | Primary | 2D | Wang et al., 2017 |
| Shear stress | Blood brain barrier | Primary | 2D/3D | Brown et al., 2015 |
| Shear stress | Blood brain barrier | Cell line | 2D/3D | Sellgren et al., 2015 |
| Shear stress | Extravasation | Primary | 3D | Jeon et al., 2015 |
| Shear stress | Vasculature | Primary | 3D | Kim et al., 2013 |
| Shear stress | Bone | Cell line | 2D | Middleton et al., 2017a,b |
| Shear stress | Bone | Primary | 3D | Altmann et al., 2014 |
| Shear stress | Vasculature | Primary | 2D | Zheng et al., 2017 |
| Shear stress | Vasculature | Primary | 2D | Venugopal Menon et al., 2018 |
| Shear stress | Vasculature | Primary | 2D | Patibandla et al., 2014 |
| Stretching | Lung | Primary and cell line | 2D | Huh et al., 2010, 2012; Benam et al., 2016; Hassell et al., 2017; Jain et al., 2018 |
| Stretching | Gut | Primary and cell line | 2D | Kim H.J. et al., 2016; Villenave et al., 2017 |
| Stretching | Heart | Primary | 2D | Ugolini et al., 2016, 2017 |
| Stretching | Muscle | Primary and cell line | 2D | Michielin et al., 2015 |
| Stretching | Vasculature | Primary | 2D | Zhou and Niklason, 2012 |
| Stretching | - | Primary | 3D | Liu et al., 2016 |
| Stretching | Heart | Primary | 3D | Marsano et al., 2016; Occhetta et al., 2018 |
| Stretching | - | Cell line | 3D | Li et al., 2016 |
| Stretching | - | - | 2D/3D | Gizzi et al., 2017 |
| Stretching | Artery | Primary | 2D | van Engeland et al., 2018 |
| Compression | Bone | Primary | 2D | Park et al., 2012 |
| Compression | Vasculature | Primary | 2D | Sticker et al., 2017 |
The dashes (-) identify studies with devices without a defined target organ, tissue or cell culture.