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Inhibiting RIP1 using necrostatin-1 limited the upregulation of RIP1 and NF-κB induced by chronic stress in D-galactose-induced aging mice. Western blot analysis of RIP1 (A), NF-κB (B), RIP3 (C), and MLKL (D) in the hippocampus. Data are expressed as the mean ± standard error of mean (SEM). ∗p < 0.05; ∗∗p < 0.01; (n = 4, one-way ANOVA followed by Turkey’s post hoc comparisons tests).
