Table 1.
Infections complications in Hematopoietic stem cells transplantation recipients.
| Type of infection | Early pre-engraftment (2-4 weeks after HSCT) | Early post-engraftment (2-3 months after HSCT) | Late phase (beyond 3 months after HSCT) |
|---|---|---|---|
| Bacterial (Gudiol et al., 2014; Kikuchi et al., 2015; Young et al., 2016; Girmenia et al., 2017; Schuster et al., 2017; Cho et al., 2018; Mikulska et al., 2018) | Gram positive bacteria (Coagulase-negative staphylococci, streptococcus pneumoniae, viridans group streptococci, staphylococcus aureus) Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) Clostridium difficile |
Gram positive bacteria (Streptococcus pneumoniae Coagulase-negative staphylococci, viridans group streptococci, staphylococcus aureus) Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) |
Encapsulated bacteria (mainly streptococcus pneumoniae and Haemophilus influenza) Pseudomonas aeruginosa Nocardia |
| Fungal(Gudiol et al., 2014; Kikuchi et al., 2015; Sahin et al., 2016; Young et al., 2016; Maertens et al., 2018) |
Candida species. Aspergillus species. |
Aspergillus species Pneumocystis jirovecii |
Aspergillus species Pneumocystis jirovecii |
| ViralLin and Liu, 2013; Sahin et al., 2016; Cho et al., 2018 | HSV (mostly reactivation of HSV latent infection) |
Mainly CMV. Community acquired viruses (mainly respiratory viruses) Other herpes viruses (EBV, HHV-6) Polyoma virus |
CMV VZV EBV (risk of PTLD) Community acquired viruses (mainly respiratory viruses) |
| Parasitic | Rarely documented | Rarely documented Toxoplasma gondii Jarque et al., 2016; Prestes et al., 2018 (usually reactivation of a latent infection). Other parasites: Jarque et al., 2016; Fabiani et al., 2017 Reactivation of latent infection or transmission from infected donors: Especially in endemic regions (Tripanozoma cruzy, Plasmodium spp. Leishmania spp) |
Rarely documented Toxoplasma gondii Jarque et al., 2016; Prestes et al., 2018 (usually reactivation of a latent infection) Other parasites: Jarque et al., 2016; Fabiani et al., 2017 Reactivation of latent infection or transmission from infected donors: Especially in endemic regions (Tripanozoma cruzy, Plasmodium spp. Leishmania spp) Primary infection with other parasites rare and may have worldwide distribution (Cryptosporidium spp, Blastocystis spp.) or limited to endemic regions: Strongyloides stercoralis |