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. 2018 Oct 9;9:404. doi: 10.3389/fgene.2018.00404

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Copyright © 2018 Iancu, Boutros, Olsen, Davis, Stewart, Eiwaz, Marzulla, Belknap, Fallgren, Edmondson, Weil and Raber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Outline of QTL detection utilizing Mantel correlations. Pairwise distances are computed between individuals/samples based on genotype at specific marker(s). This results in square matrix of genetic similarities between individuals. Multiple genetic markers can be included in the analysis by including several markers and applying the Manhattan distance to the resulting vector. A similar size matrix is computed utilizing pairwise distances in terms of phenotype. These genotype and phenotype matrices are correlated utilizing the Mantel procedure.