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. Author manuscript; available in PMC: 2018 Oct 16.
Published in final edited form as: Nat Immunol. 2018 Feb 12;19(3):279–290. doi: 10.1038/s41590-018-0046-x

Figure 6. Transient expression of Hoxb5 reprograms B cells into T lymphocytes using a Tet-Hoxb5 transgenic model.

Figure 6.

(a) Flow cytometry analysis of BFP+ B220+CD19+CD93+IgM− pro-pre-B cells in the bone marrow of a representative Tet-Hoxb5 mouse, which was maintained on drinking water with doxycycline (1mg/ml) for one week. One Tet-Hoxb5 mouse without feeding Dox water was used as negative control. (b-c) Dynamics of iT lymphocytes in PB, Spleen, and LN (b) gated from CD45.2+Ter119−Mac1− population, and iDN cells in thymus (c) gated from CD45.2+Ter119−Mac1−CD19− population of recipients transplanted with Tet-Hoxb5 pro-pre-B cells. Representative mice were analysed 4 weeks, 8 weeks and 12 weeks after transplantation. Data are representative of two independent experiments (b, c).