Table 4.
Overview of comorbidity risk assessment tools for bladder cancer
| Study | Sample size
|
Median FU |
CI | Hazard ratio
|
ORC | AUC | |||
|---|---|---|---|---|---|---|---|---|---|
| Total | RC | 90-d mortality | OCM | CSM | |||||
| Taylor 2012 [11] | 1141 | 1141 | NR | CCI | NR | NR | NR | NR | Bootstrap: 0.702 |
| Fairey 2009 [17] | 523 | 523 | 31 mo | ACE-27 | NR | ACE-27 moderate: 1.59; severe: 1.83 | ACE-27 moderate: 1.50; severe: 1.65 | NR | NR |
| Eisenberg 2013 [10] | 2403 | 2403 | 10.5 yr | CCI, ECOG | NR | CCI: 1.73 ECOG: 1.51 |
CCI: 1.16 ECOG: 1.34 |
NR | Bootstrap: 0.75 |
| Froehner 2015 [37] | 735 | 735 | 7.8 yr | LMI | NR | 1.06 | NR | NR | NR |
| Morgan 2011 [52] | 220 | 220 | NR | CCI | 1.30 (NS) | NR | NR | NR | Model: 0.75 Bootstrap: 0.71 |
| Abdollah 2012 [53] | 12 274 | 12 274 | NR | CCI | CCI 3 vs 1: 2.86 | NR | NR | NR | 0.70 |
| Williams 2017 [54] | 6582 | 6582 | NR | CCI | NR | OS CCI 3 vs 1: 2.71 | CSS, CCI 3 v 1: 1.17 | NR | OS: 0.65 CSS: 0.66 |
ACE-27 = Adult Comorbidity Evaluation 27 score; AUC = area under the receiver operating characteristic curve; CCI = Charlson CI; CI = comorbidity index; CSM = cancer-specific mortality; CSS = cancer-specific survival; ECOG = Eastern Cooperative Oncology Group performance score; FU = follow-up; LMI = Lee Mortality Index; NR = not recorded; NS = not significant; OCM = other-cause mortality; ORC = odds ratio for complications; OS = overall survival; RC = radical cystectomy.