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. 2018 Nov;25(11):587–600. doi: 10.1101/lm.048181.118

Figure 1.

Figure 1.

Taste preexposure paradigm. A complete timeline of the Taste preexposure paradigm showing all groups. Animals were divided into two groups: TPE (left) or WPE (right), then further divided into three conditioning conditions: sucrose + LiCl, sucrose + saline, and LiCl alone. Schematic demonstrates the 4-d experimental paradigm in which rats receive TPE to water (W), sodium chloride (N), and citric acid (C), via IOC infusions to the tongue for 3 d (black circles days 1–3). WPE rats underwent three identical days of exposure to water. Aversions were then conditioned on the fourth day, when exposure to sucrose (S) is immediately followed by LiCl injections (0.3 M, 0.5% of current body weight), equal dosages of saline or equal dosages of LiCl without sucrose exposure. Control rats were either given saline injections or LiCl alone. Ninety minutes after the conditioning session, rats were perfused for harvesting of GC.