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. 2018 Nov;25(11):587–600. doi: 10.1101/lm.048181.118

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© 2018 Flores et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — GCx during Taste preexposure paradigm. A complete timeline of the optogenetic (Experiment 2A) paradigm showing all groups. Rats first undergo viral injection surgery (either AAV-CAG-GFP or AAV-CAG-ArchT-GFP infused bilaterally into GC). Rats receiving AAAV-CAG-ArchT-GFP (ArchT+) are highlighted in green. Rats receiving only AAV-CAG-GFP (ArchT-) are highlighted in gray. To ensure high levels of viral infection, the optical fiber and intraoral cannulation surgery took place 4 wk after viral injection surgery. Following 7 d of recovery after the optical fiber and intraoral cannulation surgery, all rats encountered three TPE (or WPE) sessions, with 532 nm laser illumination of GC during each fluid exposure (indicated by green triangle). ArchT- groups (top three rows) involved three groups: from the top, TPE followed by sucrose + LiCl, WPE followed by sucrose + LiCl and WPE followed by sucrose + saline. ArchT+ groups (bottom two rows) involved two groups: TPE followed by sucrose + LiCl and TPE followed by sucrose + LiCl in which laser illumination was delayed by 6 h (see text). On the day following conditioning, aversion strengths are tested via sequential presentation of sucrose and water for all five groups.