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. 2018 Nov;25(11):587–600. doi: 10.1101/lm.048181.118

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© 2018 Flores et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — GCx during TPE inhibits CTA learning enhancement and impacts CTA-related c-Fos. (A) In ArchT- rats (black and white bars, left side of graph), aversions to novel sucrose were stronger following TPE (black striped bar) than following WPE (open bar)—a replication of the original behavioral result (Flores et al. 2016). ArchT+ rats receiving GCx during TPE (thin green striped bar) showed significantly weaker CTAs compared to identically run ArchT - rats (compare the middle pair of TPE bars)—demonstration that GC activity during TPE is vital for the behavioral phenomenon. GCx induced 6 h after each TPE session (thick green striped bar) did not reduce aversion strength. Finally, all conditioned groups showed learning when compared to ArchT- sham-conditioned rats (horizontal dashed line). The x-axis represents average raw sucrose consumption on test day (mL) across all groups. (B) (Left) CTA-related c-Fos expression in GC was significantly stronger in ArchT- rats (open bar), compared to ArchT+ rats (green bar)—GCx reduced CTA-induced c-Fos. (Right) Representative images of c-Fos positive somae (masked in black) for GC-intact (top) and GCx (bottom) rats, quantified by the FIJI Analyzing Particles tool. Error bars represent SEM. (*) P < 0.05.