Figure 4.

Dose-dependent reduction in mitochondrial trafficking velocity in glucose- and palmitate-treated mouse DRG neurons. A significant reduction in anterograde mitochondrial trafficking velocity was visible after 24 h of treatment with palmitate (B) concentrations that inhibit mitochondrial trafficking. Similarly, a trending reduction in retrograde mitochondrial trafficking velocity was visible after 24 h of treatment with elevated concentrations of palmitate (D). No significant differences in anterograde (A) or retrograde (C) mitochondrial trafficking velocity were evident after 24 h of 50–200 mM glucose treatment. Values are expressed as means ± sem. *P < 0.01, ordinary 1-way ANOVA with Tukey’s multiple-comparisons test.