TABLE 2.
Multifactorial analysis of fetal lung volume changes
| ANOVA | Sum of squares (type III) | DF | MS | F(DFn, DFd) | P |
|---|---|---|---|---|---|
| Interaction | 16.92 | 2 | 8.461 | F(2, 15) = 7.622 | 0.0052** |
| Condition | 29.19 | 1 | 29.19 | F(1, 15) = 26.3 | 0.0001*** |
| Time point | 421.7 | 2 | 210.9 | F(2, 15) = 190 | <0.0001**** |
| Residual | 16.65 | 15 | 1.11 |
Two-way ANOVA of effects of developmental time point (14.5, 16.5, 18.5 dpc) and environmental condition (room air or smoke exposure) on changes in fetal lung volume was sufficiently explained by the prediction model of Pearson’s correlation (R2 = 0.9689). Results show that changes in fetal lung volume depends largely on the developmental time point of the fetus (F(2, 15) = 190, P < 0.0001), which accounted for 62.11% of the observed change vs. 23.3% due to the effect of maternal cigarette smoke exposure (F(1, 15) = 26.3, P < 0.0001). **P < 0.01, ***P < 0.001, ****P < 0.0001.