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. 2017 Feb 27;31(6):2507–2519. doi: 10.1096/fj.201601074R

Figure 6.

Figure 6.

Protamine inhibits apelin-induced vasodilatation, and its activity can be reversed by heparin. Time-dependent changes of arterial blood pressure after intravenous administration at time 0 of saline (black curve, n = 5); angiotensin II (35 ng/kg; green curve, n = 5); apelin 12 (100 nmol/kg; red curve, n = 5); protamine (700 U/kg) and apelin 12 (100 nmol/kg; blue curve, n = 5); and heparin (1400 U/kg), protamine (700 U/kg), and apelin 12 (100 nmol/kg; gray curve, n = 5). Data represent means ± sem. Statistical significance between groups was assessed by using 2-way ANOVA followed by Bonferroni posttest. *P < 0.05, **P < 0.01, ***P < 0.001, angiotensin vs. saline solution; #P < 0.05, ##P < 0.01, ###P < 0.001, apelin vs. saline solution; †P < 0.05, ††P < 0.01, protamine + apelin vs. apelin; ×P < 0.05, ××P < 0.01, heparin + protamine + apelin vs. protamine + apelin.