Fig 2. Optimal cut-off value and survival analysis in primary extrahepatic cholangiocarcinoma.
(A) Identification of an optimal cut-off value for the prognosis using the log-rank plot analysis. Kaplan-Meier curves for 5-year overall survival stratified by CDO1 methylation status (B), and CDO1 methylation status and perineural invasion in low levels of CA19-9 (C), (D). Kaplan-Meier curves for the combination of CDO1 methylation and CA19-9 (E). RR: relative risk.