Table 2. Complications after HSCT.
| Complications of HSCT | Total patients: n (%) | Allogeneic HSCT: n (%) | Autologous HSCT: n (%) | p–value |
|---|---|---|---|---|
| 229 (100) | 126 (100) | 103 (100) | ||
| Complications | ||||
| yes | 170 (74.2) | 112 (88.9) | 58 (56.3) | |
| no | 59 (25.8) | 14 (11.1) | 45 (43.7) | |
|
Infections |
||||
| Viral reactivation | 36 (16.2) | 33 (26.2) | 3 (2.9) | < .001 Chi2 * |
| chronic | 4 (1.7) | 4 (3.2) | 0 (0,0) | < .001 Chi2 |
| transient | 32 (13.5) | 28 (22.3) | 4 (3.8) | |
| Severe bacterial infection/Sepsis | 12 (5,2) | 11 (8,7) | 1 (1,0) | .014 Chi2 * |
| Severe fungal infection | 4 (1,7%) | 4 (3,2) | 0 (0,0) | .129Chi |
| Severe mucosal ulcerations | 7 (3.1) | 6 (4.8) | 1 (1,0) | .133 FE |
| CNS disorders | 8 (3,4) | 8 (6,3) | 0 (0.0) | .009 FE * |
| Cardio-vascular complications | ||||
| Cardiomyopathy | 13 (5.7) | 10 (7.3) | 3 (2.9) | .151 Chi2 |
| ECG abnormalities | 25 (10.9) | 13 (10.3) | 12 (11.6) | .734 FE |
| Hyper—/ Hypotension | 24 (10.5) | 21 (16.7) | 3 (2.9) | < .001 FE * |
| Thrombosis / Embolism | 29 (12.7) | 24 (19.0) | 5 (4.9) | .001 Chi2 * |
| Pulmonary complications | ||||
| Acute respiratory insufficiency | 9 (3.9) | 9 (7.1) | 0 (0.0) | .005 FE * |
| Impaired pulmonary function | 55 (24.0) | 37 (29.4) | 18 (17.5) | .043 Chi2 * |
| Renal insufficiency | 16 (7.0) | 11 (8.7) | 5 (4.9) | .252 Chi2 |
| Transplant rejection | 2 (0.9) | 2 (1.6) | 0 (0.0) | .503 FE |
| Secondary malignancies | 1 (0.4%) | 1 (0.8) | 0 (0.0) | 1.000 FE |
| Abnormal audiogram | 26 (11.4) | 12 (9.5) | 14 (13.6) | .611 Chi2 |
| Endocrine disorders | ||||
| Total number | 116 (50.7) | 70 (55.6) | 46 (44.7) | .112 Chi2 |
| Growth | 33 (14.4) | 14 (11.1) | 19 (18.4) | .132 Chi2 * |
| Thyroid | 22 (9.6) | 12 (9.5) | 10 (9.7) | 1.000 FE |
| Gonads | 85 (38.4) | 54 (42.9) | 31 (30.1) | .055 Chi2 |
| Psychosocial problems | 18 (7.8) | 14 (11.1) | 4 (3.9) | .043 Chi2 |
Table 2 shows complications during the course of HSCT. Comparison of allogeneic and autologous HSCT patients with p-values and statistical tests used.
*Calculation of the p-value stating used tests: Chi2 = Chi-square-Test; FE = Fisher’s exact test. CI 95%; P≤0.05. * Significant at the 0.05 probability level.