Skip to main content
. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Expert Rev Anticancer Ther. 2018 Mar 16;18(5):451–461. doi: 10.1080/14737140.2018.1451749

Figure 2.

Figure 2.

Engineered T cells to counteract the immunosuppressive GBM microenvironment. Major immunosuppressive cell populations and molecules are depicted. For additional details see text. MDSCs: myeloid derived suppressor cells, DCs: dendritic cells, Tregs: regulatory T cells, PD-L1: programmed cell death protein ligand 1,

IDO: indoleamine 2,3 dioxygenase, ARG: arginase, TGFβ: transforming growth factor β. DNR: dominant negative receptor, k/o: knockout.