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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2018 Jul 25;29(11):2182–2188. doi: 10.1007/s13361-018-2028-5

Figure 4.

Figure 4.

Addition of the IMS dimension enables better quantitation in fragmentation data. Calibration curves for 10 BSA target peptides spiked into yeast and extracted in the A) LC-CID-MS and B) LC-IMS-CID-MS all-ions fragmentation spectra. Like the MS1 spectra, IMS filtering illustrated a greater dynamic range for all peptides due to the reduction of noise. A specific example of interference is illustrated in the bottom XICs for the baseline area around the transitions of YiC[+57]DNQDTISSK+ in the 10 nM BSA/yeast sample.