Table 1.
Demographic and treatment characteristics of survivors of CNS tumors, solid tumors and siblings
| Characteristic | CNS Tumor (n=665) | Solid Tumor (n=1376) | Sibling (n=726) | Pa | Pb | Pc | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | Median (Range) | N (%) | Median (Range) | N (%) | Median (Range) | |||||
| Sex | Male | 358 (53.8) | 694 (50.4) | 379 (52.2) | .15 | .54 | .44 | |||
| Female | 307 (46.2) | 682 (49.6) | 347 (47.8) | |||||||
| Age (Year) | 15.0 (12.0-17.0) | 15.0 (12.0-17.0) | 15.0 (12.0-17.0) | |||||||
| Household Income | < 40,000 | 161 (25.8) | 331 (25.9) | 133 (19.3) | .74 | .01 | <.001 | |||
| 40,000-79,999 | 199 (31.9) | 427 (33.4) | 223 (32.3) | |||||||
| >=80,000 | 264 (42.3) | 519 (40.6) | 334 (48.4) | |||||||
| Race/Ethnicity | White | 555 (87.0) | 1099 (82.3) | 600 (86.3) | .009 | .56 | <.001 | |||
| Black | 31 (4.9) | 122 (9.1) | 28 (4.0) | |||||||
| Hispanic | 35 (5.5) | 72 (5.4) | 40 (5.8) | |||||||
| Other | 17 (2.7) | 42 (3.1) | 27 (3.9) | |||||||
| Diagnosis | Astrocytoma | 382 (57.4) | ||||||||
| Medulloblastoma, | 156 (23.5) | |||||||||
| PNET | ||||||||||
| Other CNS tumors | 127 (19.1) | |||||||||
| Neuroblastoma | 703 (51.1) | |||||||||
| Wilms Tumor | 673 (48.9) | |||||||||
| No cancer | 726 | |||||||||
| Age at Diagnosis (Year) | 2.9 (0.0-9.2) | 1.5 (0.0-8.4) | ||||||||
| Time Since Diagnosis | 12.1 (8/0- | 13.2 (8.3- | ||||||||
| (Year) | 17.7) | 17.9) | ||||||||
| CRT | No | 291 (48.3) | 1192 (95.8) | 726 | <.0001 | |||||
| Yes | 312 (51.7) | 52 (4.2) | ||||||||
| CRT Dose (Gy) | Mean (SD) | |||||||||
| Posterior Fossa | 20.3 (25.3) | |||||||||
| Temporal Lobe | 23.0 (25.1) | |||||||||
| Frontal Cortex | 11.7 (18.0) | |||||||||
| Parietal or Occipital | 11.2 (17.6) | |||||||||
| Lobe | ||||||||||
| Total Dose | 27.0 (26.6) | |||||||||
| Decade of Diagnosis | 1970-1989 | 367 (55.94) | ||||||||
| 1990-1999 | 293 (44.06) | |||||||||
| SMN | No | 654 (98.3) | 1355 (98.5) | 726 | 0.83 | |||||
| Yes | 11 (1.7) | 21 (1.5) | ||||||||
| Relapse | No | 650 (97.7) | 1372 (99.7) | 726 | <.0001 | |||||
| Yes | 15 (2.3) | 4 (0.3) | ||||||||
Abbreviations: CNS, central nervous system; CRT, cranial radiation therapy; SMN, secondary malignancy.
a
CNS tumor vs.Solid tumor;
b
CNS tumor vs. Sibling controls;
c
Solid tumor vs. Sibling controls