Table 2.
Concentrations* of select analytes in human milk
| Locally collected (n = 138) | Shipped to laboratory (n = 154) | |||||
|---|---|---|---|---|---|---|
| Analytes | Median | IQR | Detectable | Median | IQR Detectable | |
| Proinflammatory panel | ||||||
| Interferon gamma (IFN | 0 | 0 - 6.22 | 37% | 0 | 0 - 7.00 | 35% |
| Interleukin 1 beta (IL-1 | 0.36 | 0 - 1.02 | 73% | 0.67 | 0.23 - 1.78 | 74% |
| Interleukin-6 (IL-6) | 0.89 | 0 - 3.02 | 59% | 1.05 | 0 - 3.48 | 57% |
| Interleukin-8 (IL-8) | 210.25 | 102.50 - 401.72 | 97% | 255.48 | 127.97 - 620.37 | 96% |
| Tumor necrosis factor-alpha (TNF | 1.06 | 0.49 - 2.26 | 59% | 0.70 | 0 - 2.02 | 58% |
|
Angiogenesis panel | ||||||
| Basic fibroblast growth factor (bFGF) | 0.65 | 0.0-1.70 | 61% | 0.76 | 0 - 1.58 | 60% |
| Fms Related Tyrosine Kinase 1 (FLT1) | 1758.01 | 1299.81 - 2353.27 | 99% | 1762.68 | 1318.11 - 2496.71 | 99% |
| Placenta growth factor (PLGF) | 67.29 | 37.04 - 118.33 | 99% | 72.96 | 39.13 - 144.45 | 99% |
| Vascular endothelial growth factor D (VEGF-D) | 293.81 | 229.89 - 449.74 | 99% | 274.81 | 188.84 - 411.39 | 98% |
|
Singleplex assays | ||||||
| Adiponectin | 21.15 | 15.15 - 28.46 | 100% | 20.26 | 14.43 - 26.27 | 100% |
| Epidermal growth factor (EGF) | 4373.99 | 2991.79 - 6053.52 | 100% | 4480.19 | 2881.58 - 5987.60 | 100% |
| Fas ligand (FASL) | 44.31 | 32.62 - 59.88 | 100% | 43.63 | 30.88 - 56.99 | 100% |
| Leptin | 605.21 | 0 - 1433.18 | 70% | 1047.06 | 334.97 - 2208.45** | 80% |
*
pg/mL for all analytes except adiponectin, which is μg/mL; analytes with <25% detectability excluded from table. If both duplicate levels were above the lower limit of detection (LLOD), the final calculated concentration was the mean of the two levels. If one technical replicate level was above the LLOD and one was below, then the final calculated concentration was the mean of the analyte above the LLOD and 1/2 the LLOD. If both analytes were below the LLOD then the result was recorded as zero.
**
Chi square = 4.96, p = 0.03