Skip to main content
. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Am J Transplant. 2018 May 7;18(11):2647–2662. doi: 10.1111/ajt.14868

FIGURE 4. Memory NK responses to MCMV infected allografts differ according to recipient virus dose during primary infection.

FIGURE 4

B6 mice were infected with MCMVΔm157 at either low dose (102 pfu) or high dose (104 pfu) to induce NK memory, and D+/R+ transplants were performed as in Figure 3. Memory NK responses from low dose and high dose infected recipients were compared to primary NK responses in D+/R− transplants.

(A, B) Allograft IFN-γ+ NK cells (A) or GzB+ NK cells (B) were compared between D+/R−, D+/R+ low dose (102) and D+/R+ high dose (104) infected recipients.

(C) Spleens from pre-transplant low dose (102) or high dose (104) MCMV+ B6 mice were analyzed for pre-transplant baseline IFN-γ+ and GzB+ NK cells.

(D, E) Splenic IFN-γ+ NK cells (D) or GzB+ NK cells (E) were compared between D+/R−, D+/R+ low dose (102) and D+/R+ high dose (104) infected recipients.