Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparative performances of the time-to-event Bayesian optimal interval (TITE-BOIN), rolling six (R6), and time-to-event continual reassessment method (TITE-CRM) designs with respect to that of the 3+3 design. (a and b) Relative percentages of correct selection (PCS) of the MTD; (c and d) Relative percentages of patients assigned to the MTD. The target DLT rate in scenarios 1-8 is 0.2, while that in scenarios 9-16 is 0.3. The accrual rate is 2 patients/month. A higher value is better.
