Table 2.

Evaluated Cut-off Thresholds for Defining Early and Late Recurrence Based on the Prognosis After Recurrence

Evaluated Cut-off	P Value	Potential Early Recurrence Cohort				Potential Late Recurrence Cohort
		N	RFS (mo)	PRS (mo)	OS (mo)	n	RFS (mo)	PRS (mo)	OS (mo)
3 mo	3.43×10–1	85	1.6	7.9	9.1	604	13.7	7.5	23.7
4 mo	1.10×10–2	123	2.1	6.9	9.8	630	14.6	7.7	24.4
5 mo	6.79×10–4	157	2.6	6.5	9.2	596	15.1	7.9	25.1
6 mo	8.70×10–5	182	3.3	6.5	9.9	571	15.6	8.0	25.9
7 mo	1.70×10–5	222	3.8	6.5	10.1	531	16.6	8.0	26.6
8 mo	3.73×10–7	244	4.0	6.4	10.2	509	17.1	8.3	28.1
9 mo	1.29×10–9	277	4.4	6.1	10.7	476	18.1	8.9	29.6
10 mo	1.68×10–11	319	5.3	6.0	11.2	434	19.4	9.7	31.5
11 mo	2.56×10–11	353	5.9	6.2	12.3	400	20.2	10.3	32.5
12 mo	3.31×10–13	388	6.5	6.1	13.0	365	20.9	10.8	34.6
13 mo	4.21×10–13	410	6.8	6.2	13.6	343	23.0	10.8	35.6
14 mo	6.9810–13	437	7.1	6.2	13.9	316	24.5	10.9	38.5
15 mo	3.47×10–12	462	7.5	6.4	14.4	291	25.7	10.6	40.2
16 mo	1.49×10–12	489	8.4	6.6	14.9	264	26.9	10.9	43.3
17 mo	4.75×10–11	508	8.6	6.7	15.2	204	27.6	11.7	44.9
18 mo	3.58×10–12	526	8.9	6.7	15.7	227	29.0	11.8	47.8
19 mo	1.21×10–11	543	9.1	6.9	16.0	210	30.6	12.1	48.4
20 mo	4.21×10–11	564	9.3	6.9	16.6	189	31.9	13.4	51.3

Shown in bold is the optimal cut-off threshold with the lowest P value. RFS indicates recurrence-free survival; PRS, post-recurrence survival; OS, overall survival.