Table 2. Pathological summary and distribution of TDP-43 pathology in MSA.
| Case | Age | Sex | AD | AGD | HS | LP | Distribution, morphology, and severity of TDP-43 pathology | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AM | HP | EC | DG | TH | BF | HT | MB | PN | ME | CW | MC | |||||||
| MSA-1 | 55 | F | - | - | - | - | + P |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-2 | 57 | F | - | - | - | - | + P |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-3 | 68 | F | - | - | - | - | + P |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-4 | 73 | F | - | - | - | - | + P |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-5 | 82 | F | - | - | - | - | + P/N |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-6 | 85 | M | - | - | - | - | + P/N |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-7 | 91 | M | - | - | - | - | + P/N |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-8 | 88 | M | + | - | + | - | + N |
- | - | - | - | - | - | - | - | - | - | - |
| MSA-9 | 70 | F | - | - | - | + | + N/S |
+ N/D |
+ N |
+ N |
- | - | - | - | - | - | - | - |
| MSA-10 | 87 | F | + | - | - | - | +++ N/D |
++ N/D |
++ N |
++ N |
- | - | - | - | - | - | - | - |
| MSA-11 | 67 | M | - | + | - | - | - | - | - | + N |
+ N/G/D |
++ G |
- | + I/G/D |
+ G/N |
- | - | - |
| MSA-12 | 84 | M | - | + | + | - | +++ N/D/S/V |
+++ N/FN/I/V/S |
+++ N/D/V |
++ N |
+ G |
- | ++ N/G |
+ G |
- | - | - | - |
| MSA-13 | 61 | M | - | + | - | - | + N |
+++ N/FN/G/P |
++ G |
- | + G/N |
+ G |
+ N/D |
+ N/G/D |
++ G |
+++ N/G/D |
+ G |
++ G/S |
Semiquantitative assessment of severity in TDP-43 pathology: - indicates negative, + indicates mild, ++ indicates moderate, and +++ indicates severe. Abbreviations: AD, Alzheimer's disease; AGD, argyrophilic grain disease; AM, amygdala; BF, basal forebrain; CW, cerebellar white mater; D, dystrophic neurites; DD, disease duration; DG, dentate gyrus; EC, entorhinal cortex; FN; fine neurites; G, glial cytoplasmic inclusions; HP, hippocampus; HS, hippocampal sclerosis; I, neuronal intranuclear inclusions; LP, Lewy-related pathology; MB, midbrain; MC, motor cortex; ME, medulla; N, neuronal cytoplasmic inclusions; P, subpial astrocytic inclusions; PN, pontine nucleus; TH, thalamus; V, perivascular inclusions.