TABLE 1.

GWAS summaries

	Trait			GWAS			SNPs for PRS
GWAS	h2	h2chip	PRS r2	Cases	Controls	SNPs	PING	PNC
ADHDa	0.76f	0.28k	0.001l	2960	4519	1 206 462	5363	—
ASDb	0.90g	0.17k	*0.008m	3303	3428	9 499 590	10 179	3787
BIPc	0.90h	0.25k	0.028	7481	9250	2 427 221	13 965	—
MDDd	0.31–0.42i	0.21k	*0.006	9240	9519	1 235 110	5622	3752
SCZe	0.81j	0.23k	0.184	34 241	45 604	9 444 231	17 119	—

The heritability (h²) and chip heritability (h²_chip) are representative values for each disorder and suggest a large contribution of common genetic factors to disease liability. The within-trait PRS predictive power (PRS r²) of the GWAS results varies approximately according to the sample sizes.

^*Note that the VE by PRS reported here are likely underestimates for the PRS used here. The ASD and MDD GWAS used in these studies to create PRS were subsets (40% and 80%, respectively) of the sample used for this study.

^aNeale et al³⁹.

^bCross-Disorder Group of the Psychiatric Genomics⁴⁰.

^cThe Psychiatric GWAS Consortium Bipolar Disorder Working Group⁴¹.

^dMajor Depressive Disorder Working Group of the Psychiatric GWAS Consortium et al⁴².

^eSchizophrenia Working Group of the Psychiatric Genomics Consortium⁴³.

^fFaraone and Mick⁴⁴.

^gFreitag⁴⁵.

^hCraddock and Sklar⁴⁶.

ⁱSullivan et al⁴⁷.

^jSullivan et al⁴⁸.

^kCross-Disorder Group of the Psychiatric Genomics Consortium et al⁴⁹.

^lHamshere et al⁵⁰.

^mAnney et al⁵¹.