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. 2018 Oct 16;9:4162. doi: 10.1038/s41467-018-06569-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Left medial orbitofrontal cortex (mOFC) cortical thickness correlates with both olfactory identification and spatial memory. a We measured mOFC cortical thickness using CIVET. Within spatial learners, left mOFC cortical thickness correlated positively with olfactory identification (left) (r = 0.33, Bootstrap BCa 95% CI [0.02, 0.64]), and correlated negatively with average navigational learning errors (right) (r = −0.49, Bootstrap BCa 95% CI [−0.69, −0.24]). b Within response learners, left mOFC cortical thickness did not correlate with olfactory identification (left) (r = 0.23, Bootstrap BCa 95% CI [−0.07, 0.59]). Interestingly, it did correlate positively with average navigational learning errors (right) (r = 0.42, Bootstrap BCa 95% CI [0.13, 0.67]), which indicates that the mOFC may interfere with stimulus-response learning. These results indicate that the relationship between olfactory identification, navigation, and mOFC cortical thickness is specific to those who use a hippocampal-dependent navigation strategy (spatial memory)