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. 2018 Oct 16;8:15286. doi: 10.1038/s41598-018-33306-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced tumor growth in mice implanted with mGas1-BTICs. (A) MRI images at 7 weeks post-implantation (on day 50) showed very large tumor growth in control mice implanted with BT025, whereas in mGas1-BT025 mice the tumor was significantly smaller (quantitation shown in B). Similar results were documented for mice implanted with BT048 (MRI performed on day 70; C,D) that the mice were engrafted with tumor cells was verified by the mice dying at later periods (see Fig. 4B). **p < 0.01, ***p < 0.001 with unpaired t-test (n = 5 for BT025 cells, and n = 4 for BT048 cells; error bar indicates sem). (E) In mice killed (n = 3 in each group) immediately after MRI, H&E staining showed massive tumor growth in a representative control (BT048) mouse which was barely evident in a representative mGas1-BT048 animal. Rank order analysis (F), where the higher number depicts a larger tumor area. *p < 0.05 (Mann-Whitney U test).