Fig. 1.

Phenotypes tested and study design. a Categories of phenotypes assessed in the 23andMe, Genomics plc UK Biobank, FINRISK, and CHOP cohorts. b Manual phenotype mapping was performed to identify phenotypes shared between cohorts. One hundred and forty-five phenotypes were captured with at least 20 cases in at least 2 cohorts. After PheWAS in each cohort separately, the 145 phenotypes were meta-analyzed to increase statistical power and enable systematic comparisons of results between cohorts. c The 145 mapped phenotypes (see Supplementary Table 2) represent a broad spectrum of phenotypic categories and are captured with variable case:control ratios in the cohorts tested