Table 2.
Cohorts included in this study
| Cohort | Participants geographic distribution | Phenotypes source | N binary endpoints testeda | Max sample size |
|---|---|---|---|---|
| 23andMe | 89% USA (adult) | Questionnaire-based self-reports | 654 | 671,151 |
| Genomics plc UK Biobank | 100% UK (adult) | Questionnaire-based self-reports, medical interviews and follow-up | 90 | 112,337 |
| FINRISK | 100% Finns (adult) | National health registries (ICD8,9,10) | 278 | 21,371 |
| CHOP | 100% USA (pediatric) | Electronic health records (ICD9-CM) | 870 | 12,044 |
| Genomics plc GWAS | Mixed | Mixed—multiple independent disease-specific cohorts | 34 | - |
aNumber of binary endpoints with N cases ≥ 20