Fig. 5. Therapeutic effects of vinblastine in a Brca1-deficient tumor transplantation model.

a, b Overview of the allograft model and drug treatments. Eight spontaneously developed mammary tumors were collected from Brca1^co/coMMTV-Cre mice and transplanted into nude mice. Tumor growth was tested following treatment with vehicle or vinblastine (VBL; 0.5 mg/kg, IP, 5 times/week). After the tumor of any mouse implanted with the same original tumor reached ~3000 mm³, all the mice implanted with that tumor were sacrificed and examined. c Summary of the allograft experiment. The values represent the means ± SD. d Responses of allotransplanted Brca1-mutant mammary tumors to vinblastine. **P < 0.01. e Histological analysis of tumors from vehicle-treated and vinblastine-treated mice. Areas highlighted by dotted lines represent the stromal region. In hematoxylin and eosin (H&E) staining images, the panels at the right are a magnification of the boxed areas in the adjacent panels. Scale bars: 50 μm