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. 2018 Oct 16;8:15280. doi: 10.1038/s41598-018-33599-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Significantly enriched activated or inhibited pathways after infection with N67 or 17XNL parasites. (a) Flowchart of experimental procedures conducted for this work. The methods and experimental procedures are as described in Materials and Methods. (b) Parasitemia curves from mice infected with four Plasmodium yoelii strains/subspecies. N67C, P. y. nigeriensis N67C; N67, P. y. nigeriensis N67; YM, P. y. yoelii YM; 17XNL, P. y. yoelii 17XNL. Arrows indicate time points of host death. C57BL/6 mice were injected i.v. with 10 × 10⁶ infected red blood cells (iRBCs) and daily parasitemia (percentage of iRBCs) were obtained after counting Giemsa stained thin blood smears. (c) Significantly enriched and activated pathways day 1 post infection with N67. The numbers on top of the bars are z-scores. A positive z-score suggests activation of a pathway. (d) Significantly and negatively enriched pathways day 4 post infection with N67 or 17XNL. The numbers on top of the bars are z-scores. A negative z-score indicates inhibition of a pathway. The pathway analyses were performed using Ingenuity Pathway Analysis (IPA).