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. 2018 Oct 16;8:15280. doi: 10.1038/s41598-018-33599-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of gene expression in the Th1 pathway in mice infected with N67. Genes differentially expressed in N67-infected and uninfected mice with a cutoff value of 1.2-fold or larger changes were selected for analysis of gene interaction networks that were generated through the use of IPA (QIAGEN Inc., https://www.qiagenbio informatics.com/products/ingenuity-pathway-analysis). Expression and interaction network of key genes in Th1 pathways day 1 (a) and day 4 (b) post infection with N67. Red, up-regulated genes; green, down-regulated genes. Darker colors suggest higher up- or down-regulated, respectively. Symbols for molecular functions are as presented in the side box. Note: many molecules in red (up-regulated expression) day 1 post infection became green (inhibited) or gray (similar to uninfected control) day 4 post infection.