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. 2018 Oct 16;9:4297. doi: 10.1038/s41467-018-06653-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — CD8⁺ TILs in breast tumors have elevated frequencies of PD-1⁺ EOMES⁺ cells. a CD8⁺ T cells from bcPBMCs, bcTumor, and melTumor were analyzed by flow cytometry for expression of T-bet, Eomes, and PD-1 as shown in representative contour plots. b Graph depicts the percentage of Eomes and T-bet expressing populations of non-naive CD8⁺ T cells in bcPBMCs, bcTumor, and melTumor. c Non-naive CD8⁺ T cells were analyzed for expression of Eomes and T-bet and gated as shown in representative contour plots. c Graph depicts the percentage of non-naive CD8⁺ T cells composed of PD-1⁺ Eomes⁺ cells in bcPBMCs, bcTumor, and melTumor. d Normalized values of PD-1 expression on non-naive CD8⁺ T cells in matching bcPBMC and bcTumor samples are shown. Each symbol represents data from a unique patient sample. Significance was calculated using one-way ANOVA and Holm–Sidak multiple comparison tests b, c or an unpaired Student's t-test (d); *p < 0.05; **p < 0.01; ***p < 0.001