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. 2018 Oct 10;9:1370. doi: 10.3389/fphys.2018.01370

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Copyright © 2018 Zhang, Somers, Becari, Polonis, Pfeifer, Allen, Kellogg, Covassin and Singh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adipose Tissue p53 Activation, Fibrosis and Cell Size. Representative Western blots and graph showing expression of phosphorylated p-53 (A) in abdominal subcutaneous (1, white bars) and visceral (2, gray bars) fat depots. Representative trichrome stained images (B) and graphs quantifying fibrosis (C) and average adipocyte size (D) from subcutaneous and visceral fat depots. Data are presented as median and interquartile range. Fiskars depict minimum and maximum values. –RAAS: data from AT of subjects not taking any RAAS related drugs. +RAAS:data from AT of individuals taking RAAS targeted drugs. P-values were determined using repeated ANOVA.