Table 2.

Transcription of RAS components in AT.

mRNA ratio	-RAAS (n = 20)		+RAAS (n = 10)		P-Value
	Subcutaneous	Visceral	Subcutaneous	Visceral	Depot	Drug	Depot∗Drug
AGT/GAPDH	0.0059 (0.0122-0.0025)	0.0286 (0.0391-0.0162)	0.0046 (0.0107-0.0032)	0.0226 (0.0354-0.0134)	<0.001	0.55	0.7817
RENIN/GAPDH	ND	ND	ND	ND	-	-	-
ACE/GAPDH	0.0056 (0.0129-0.0045)	0.0287 (0.0452-0.0168)	0.0062 (0.0223-0.0029)	0.024 (0.0415-0.0116)	<0.001	0.887	0.661
Chymase/GAPDH	0.0051 (0.0076-0.0015)	0.0106 (0.0191-0.0052)	0.0036 (0.0148-0.0004)	0.0076 (0.0135-0.0057)	0.001	0.522	0.614
ACE2/GAPDH	0.0002 (0.0005-0.0002)	0.0016 (0.0034-0.0011)	0.0002 (0.0013-0.0001)	0.0028 (0.004-0.0015)	<0.001	0.242	0.93
AT1R/GAPDH	0.0011 (0.0017-0.0004)	0.0017 (0.0032-0.001)	0.0015 (0.0017-0.0012)	0.002 (0.0025-0.0011)	0.03	0.595	0.269
AT2R/GAPDH	0.0003 (0.0008-0.0002)	0.001 (0.0013-0.0007)	0.0002 (0.0008-0.0002)	0.0012 (0.0025-0.0005)	<0.001	0.956	0.265
MASR/GAPDH	0.0005 (0.0012-0.0002)	0.0009 (0.0014-0.0003)	0.0004 (0.0011-0.0001)	0.0013 (0.0067-0.0004)	0.011	0.786	0.058
P53/GAPDH	0.0036 (0.0454-0.0015)	0.0456 (0.0673-0.034)	0.0039 (0.0785-0.0015)	0.0607 (0.0786-0.0318)	<0.001	0.642	0.6613
Pro-renin receptor/GAPDH	0.1402 (0.1838-0.0339)	0.0874 (0.1518-0.0533)	0.1283 (0.1926-0.061)	0.0589 (0.1311-0.0401)	0.498	0.343	0.735

Data presented as median and interquartile range. –RAAS refers to measures obtained from AT of subjects not taking any RAAS related drugs. +RAAS refers to measures obtained from AT of subjects prescribed RAAS targeted drugs. P-values were determined using repeated ANOVA. ND: not detected. Significant P-values are bolded.