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. 2018 Oct 10;8:376. doi: 10.3389/fonc.2018.00376

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Copyright © 2018 Namba, Sogawa, Okusha, Kawai, Itagaki, Ono, Murakami, Aoyama, Ohyama, Asaumi, Takigawa, Okamoto, Calderwood, Kozaki and Eguchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome and morphologies of colon cancer cells with different metastatic potentials. (A) Heat map analysis of absolute expression levels of ABC genes. Left, all ABC genes. Right, top 16 ABC genes expressed in LuM1 cells. C, Colon26; L, LuM1, N, NM11. (B,C) Relative mRNA levels of Abcg1 (B) and Abcg2 (C) analyzed using RT-qPCR. n = 4, biological replicates. *p < 0.05 (Mann-Whitney test). The mRNA levels were normalized with the levels of an internal control Hprt1. (D,E) Representative photomicrographs of LuM1, NM11, and Colon26 cells at day 1 to day 6 (D) and day 4 (E) post-seeding period. Cells were cultured in a serum-containing medium on 2D culture plates. Scale bar, 200 μm. Arrows indicate cellular aggregates. Enlarged images of cells at day 4 was shown in (E).