Table 1.
Activity of drugs against non-replicating M. abscessus.
| Compound | MBC90 (μM) |
|---|---|
| Niclosamide | 8.4 ± 0.5 |
| Amikacin | 16 ± 0.5 |
| Kanamycin | 39 ± 2.3 |
| Ebselen | >100 |
| Cefoxitin | >200 |
| Tiacumicin | >200 |
| Rifampicin | >200 |
| Clarithromycin | >200 |
| Imipenem | >200 |
| Linezolid | >200 |
| Azithromycin | >200 |
| Ethambutol | >200 |
| Ciprofloxacin | >200 |
| Levofloxacin | >200 |
| Moxifloxacin | >200 |
Nutrient-starved bacteria were exposed to compounds for 48 h, alamarBlue was added, and RFU measured after 24 h. MBC90 is the concentration required to reduce alamarBlue turnover by 90% as determined by the Gompertz equation. Data are mean ± SD of at least two independent biological replicates.