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. 2018 Oct 10;12:352. doi: 10.3389/fncel.2018.00352

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Copyright © 2018 Prajeeth, Dittrich-Breiholz, Talbot, Robert, Huehn and Stangel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of distinct transcriptional changes induced by Th1-derived effectors in microglia and astrocytes. A four-way plot was generated using 3170 DEGs enriched between microglia and astrocytes based on fold changes ≥2.0 and a false discovery rate of 0.01 (corrected p < 0.01) selection criteria. FC value was adjusted to 1 for those genes where corrected p > 0.05 in either of the cell type. log₂ (fold change) values of astrocytes was plotted against microglia. Blue dots represent common regulated genes, red dots are genes more specifically regulated in microglia and the green dots indicate astrocyte specific genes.