Table 1.
Genes highly regulated in microglia and astrocytes in response to Th1-derived effectors.
| Entrez Gene ID | Gene symbol | log2 FC | log2 FC (Microglia) |
|---|---|---|---|
| (A) ASTROCYTES | |||
| TOP UPREGULATED GENES | |||
| 17329 | Cxcl9 | 11.98624 | 11.21897 |
| 24108 | UBD | 11.44265 | 5.77813 |
| 17472 | GBP6 | 10.99735 | 10.86459 |
| 225594 | Gm4841 | 10.26361 | 9.144518 |
| 20306 | Ccl7 | 9.730344 | 5.962017 |
| 74481 | BATF2 | 9.566627 | 6.860566 |
| 100039796 | Tgtp1/Tgtp2 | 9.476637 | 9.217602 |
| 215900 | CALHM6 | 9.266997 | 6.631192 |
| 16149 | CD74 | 8.886718 | 5.191365 |
| 238393 | Serpina3g | 8.834784 | 11.93777 |
| TOP DOWNREGULATED GENES | |||
| 20606 | SSTR2 | −4.026092 | nr |
| 93732 | ACOX2 | −3.808076 | nr |
| 107585 | DIO3 | −3.733354 | nr |
| 15446 | HPGD | −3.663572 | −6.536193 |
| 100559 | UGT2B28 | −3.657526 | nr |
| 17863 | MYB | −3.640042 | nr |
| 12818 | COL14A1 | −3.630289 | nr |
| 53318 | Pdlim3 | −3.406401 | nr |
| 54612 | SFRP5 | −3.295135 | nr |
| 381107 | TMEM232 | −3.286881 | nr |
| Entrez Gene ID | Gene symbol | log2 FC | log2 FC (Astrocytes) |
| (B) MICROGLIA | |||
| TOP UPREGULATED GENES | |||
| 20715 | Serpina3g | 11.93777 | 8.834784 |
| 17329 | Cxcl9 | 11.21897 | 11.98624 |
| 17472 | GBP6 | 10.86459 | 10.99735 |
| 66857 | PLBD1 | 10.30093 | 4.26122 |
| 20307 | Ccl8 | 9.944667 | 7.576167 |
| 110454 | Ly6a | 9.927621 | 7.475109 |
| 16161 | IL12RB1 | 9.578259 | 6.742087 |
| 108116 | SLCO3A1 | 9.568786 | 2.002523 |
| 384059 | Tlr12 | 9.271939 | 6.427522 |
| 100039796 | Tgtp1/Tgtp2 | 9.217602 | 9.476637 |
| TOP DOWNREGULATED GENES | |||
| 101488 | SLCO2B1 | −7.188292 | −3.105208 |
| 321019 | GPR183 | −6.715591 | −2.320636 |
| 15446 | HPGD | −6.536193 | −3.663572 |
| 69574 | CMBL | −6.407914 | −1.909581 |
| 56811 | DKK2 | −6.055695 | nr |
| 13051 | CX3CR1 | −5.952334 | nr |
| 56792 | STAP1 | −5.834989 | nr |
| 117590 | ASB10 | −5.819413 | nr |
| 71738 | MAMDC2 | −5.717594 | −1.296311 |
| 78771 | MCTP1 | −5.53596 | nr |