Table 2.
IPA upstream analysis; top10 upstream regulators listed for astrocytes and microglia.
| Upstream regulator | Molecule type | Predicted activation state | Activation z-score | p-value of overlap |
|---|---|---|---|---|
| (A) ASTROCYTES | ||||
| IFNG | Cytokine | Activated | 12.513 | 1.36E-65 |
| STAT1 | Transcription regulator | Activated | 8.875 | 4.43E-56 |
| IRF7 | Transcription regulator | Activated | 8.32 | 2.04E-52 |
| Ifnar | Group | Activated | 7.487 | 3.32E-51 |
| TRIM24 | Transcription regulator | Inhibited | −7.17 | 7.32E-47 |
| poly rI:rC-RNA | Biologic drug | Activated | 9.514 | 1.06E-45 |
| Interferon alpha | Group | Activated | 8.228 | 2.88E-42 |
| lipopolysaccharide | Chemical drug | Activated | 9.334 | 3.07E-41 |
| IRF3 | Transcription regulator | Activated | 7.422 | 8.60E-39 |
| (B) MICROGLIA | ||||
| Lipopolysaccharide | Chemical drug | Activated | 9.95 | 6.14E-61 |
| IFNG | Cytokine | Activated | 11.559 | 3.56E-60 |
| Ifnar | Group | Activated | 7.234 | 1.01E-46 |
| STAT1 | Transcription regulator | Activated | 7.957 | 1.70E-45 |
| poly rI:rC-RNA | Biologic drug | Activated | 8.902 | 1.34E-44 |
| Interferon alpha | Group | Activated | 7.558 | 5.36E-44 |
| IRF7 | Transcription regulator | Activated | 8.381 | 2.86E-43 |
| IL10RA | Transmembrane receptor | Inhibited | −9.492 | 2.83E-41 |
| TNF | Cytokine | Activated | 6.79 | 6.11E-37 |
| IRF3 | Transcription regulator | Activated | 7.534 | 4.54E-36 |